CJO February 2025: Featured Highlights on Glaucoma

The following CJO Highlight summarizes key findings from the journal article “Effect of ginkgo biloba extract on macula and peripapillary perfusion examined using optical coherence tomography angiography.”¹

This pilot study investigated the effects of Ginkgo Biloba Extract (GBE) supplementation on macular and peripapillary perfusion in patients with early-to-moderate primary open-angle glaucoma. Despite promising clinical studies suggesting potential vascular and neuroprotective benefits of GBE, results of this study did not show significant clinical or statistical improvements in perfusion density over a 4-month supplementation period. The study observed a small, statistically significant decrease in peripapillary perfusion density in the GBE group, but this change was likely due to chance, as the control group also showed a small change in the same direction. In this pilot study, the authors could not draw conclusions about the presence or absence of neuroprotective effects of GBE. Further research with larger sample sizes and longer follow-up periods is needed to clarify GBE’s potential benefits in glaucoma management.

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Reference:

1. Hodgson K, Palakkamanil MM, Zhang A, Dyachok OM, Smith CA, Nicolela MT, Chauhan BC, Shuba LM. Effect of ginkgo biloba extract on macula and peripapillary perfusion examined using optical coherence tomography angiography. Can J Ophthalmol. 2025 Feb 25:S0008-4182(25)00035-3. doi: 10.1016/j.jcjo.2025.01.015. Epub ahead of print. PMID: 39961352.

Submitted by: Audrey-Anne Lapierre